Article

Primate-specific ZNF808 is essential for pancreatic development in humans

2021-08-23

Abstract excerpt

<h4>Summary</h4> Identifying genes linked to extreme phenotypes in humans has the potential to highlight new biological processes fundamental for human development. Here we report the identification of homozygous loss of function variants in the primate-specific gene ZNF808 as a cause of pancreatic agenesis. ZNF808 is a member of the KRAB zinc finger protein (KZFPs) family, a large and rapidly evolving group of ep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8b3b0ded-e0b1-5d65-b3b2-f433d9f8efd3
DOI: 10.1101/2021.08.23.21262262

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Primate-specific ZNF808 is essential for pancreatic development in humansDOI 10.1101/2021.08.23.21262262Read

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements.Semantic proximity Read

Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identitySemantic proximity Read

A human-specific structural variation at the <i>ZNF558</i> locus controls a gene regulatory network during forebrain developmentSemantic proximity Read

The TALE never ends: A comprehensive overview of the role of PBX1, a TALE transcription factor, in human developmental defects.Semantic proximity Read

Cis-regulatory similarities in the zebrafish and human pancreas uncover potential disease-related enhancersSemantic proximity Read

Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neuronsSemantic proximity Read

A human-specific regulatory mechanism revealed in a preimplantation modelSemantic proximity Read

Single-Cell Multi-Omic Roadmap of Human Fetal Pancreatic DevelopmentSemantic proximity Read

KZFP-mediated variable DNA methylation of a primate-specific transposon is linked to type I diabetes in humansSemantic proximity Read

Temple syndrome and Kagami-Ogata syndrome: clinical presentations, genotypes, models and mechanisms.Semantic proximity Read

Dynamic changes in the epigenomic landscape regulate human organogenesis and link to developmental disorders.Semantic proximity Read

Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.Semantic proximity Read