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Article

The KZFP/KAP1 system controls transposable elements-embedded regulatory sequences in adult T cells

2019-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Transposable elements-embedded regulatory sequences (TEeRS) are subjected to early embryonic repression through sequence-specific recruitment of KRAB zinc finger proteins (KZFPs), their cofactor KAP1/TRIM28 and associated chromatin modifiers. This modulates the TEeRS-mediated regulation of gene expression in embryonic stem cells (ESCs) and leads to DNA methylation-induced silencing. However, KZF...

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Literature Corpus work
89db9abb-170f-5cfa-aed5-e9cc015098b9
DOI
10.1101/523597
Open publication

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The KZFP/KAP1 system controls transposable elements-embedded regulatory sequences in adult T cellsDOI 10.1101/523597
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