Article

MicroRNA-29a enhances and preserves stem-like CD8 T cell differentiation by regulating master epigenetic circuits of exhaustion

2026-05-28

Abstract excerpt

CD8 T cells mediate protective immune responses. However, persisting antigens such as chronic viruses or tumors redirect CD8 T cell differentiation to a sub-optimal, epigenetically defined state called exhaustion. Exhausted T cells (T EX ) lose their ability to persist long-term and to initiate functional memory responses. Checkpoint inhibitor blockade temporarily restores effector functions, but immune reinvigor...

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Literature Corpus work: d87e9b1b-8951-5aa9-95b5-88f15934c552
DOI: 10.64898/2026.05.25.727439

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