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Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

17 Nov 2021

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for patients with B cell malignancies and is now being developed for solid tumors and chronic viral infections. Although clinical trials have demonstrated the curative potential of CAR T cell therapy, a substantial and well-established limitation is the heightened contraction and transient persistence of CAR T cells during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34788079
DOI: 10.1126/scitranslmed.abh0272

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