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T Cell Exhaustion

2 Jan 2024

Abstract excerpt

T cell responses must be balanced to ensure adequate protection against malignant transformation and an array of pathogens while also limiting damage to healthy cells and preventing autoimmunity. T cell exhaustion serves as a regulatory mechanism to limit the activity and effector function of T cells undergoing chronic antigen stimulation. Exhausted T cells exhibit poor proliferative potential; high inhibitory...

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PMID: 38166256
DOI: 10.1146/annurev-immunol-090222-110914

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