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Article

BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells.

Nature immunology - 1 Mar 2021

Yao Chen, Lou Guohua, Sun Hong-Wei, Zhu Ziang, Sun Yi, Chen Zeyu, Chauss Daniel, Moseman E Ashley, Cheng Jun, D'Antonio Marc A, Shi Wangke, Shi Junwei, Kometani Kohei, Kurosaki Tomohiro, Wherry E John, Afzali Behdad, Gattinoni Luca, Zhu Yuwen, McGavern Dorian B, O'Shea John J, Schwartzberg Pamela L, Wu Tuoqi

Abstract excerpt

During chronic infection and cancer, a self-renewing CD8+ T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8+ T cells diverge from other CD8+ subsets early after chronic viral infection. However, pathways guarding stem-like CD8+ T cells against terminal exhaustion remain unclear. Here, we show that the gene encoding transcriptional repressor BACH2...

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Identifiers

PMID: 33574619
DOI: 10.1038/s41590-021-00868-7
PMCID: PMC7906956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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