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Article

Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis.

The Journal of experimental medicine - 5 Jun 2017

Abdelsamed Hossam A, Moustaki Ardiana, Fan Yiping, Dogra Pranay, Ghoneim Hazem E, Zebley Caitlin C, Triplett Brandon M, Sekaly Rafick-Pierre, Youngblood Ben

Abstract excerpt

Antigen-independent homeostasis of memory CD8 T cells is vital for sustaining long-lived T cell-mediated immunity. In this study, we report that maintenance of human memory CD8 T cell effector potential during in vitro and in vivo homeostatic proliferation is coupled to preservation of acquired DNA methylation programs. Whole-genome bisulfite sequencing of primary human naive, short-lived effector memory (TEM),...

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Identifiers

PMID: 28490440
DOI: 10.1084/jem.20161760
PMCID: PMC5461005

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CCR7

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