Article
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology - 1 Sept 2017
Zanon Veronica, Pilipow Karolina, Scamardella Eloise, De Paoli Federica, De Simone Gabriele, Price David A, Martinez Usatorre Amaia, Romero Pedro, Mavilio Domenico, Roberto Alessandra, Lugli Enrico
Abstract excerpt
Human T memory stem (TSCM ) cells with superior persistence capacity and effector functions are emerging as important players in the maintenance of long-lived T-cell memory and are thus considered an attractive population to be used in adoptive transfer-based immunotherapy of cancer. However, the molecular signals regulating their generation remain poorly defined. Here we show that curtailed T-cell receptor...
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