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Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints

1 Apr 2025

Abstract excerpt

Background MicroRNAs (miRNAs) are epigenetic regulators of T cell maturation and exhaustion. However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear. This study focuses on miR-379-5p, which counteracts T cell exhaustion and enhances antitumor responses. Methods Native CD8+ T cells were isolated from the blood of healthy donors and subjected to chronic stimulation to...

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PMID: 40221151
DOI: 10.1136/jitc-2024-010363

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