Article

dirCLIP profiles variant-specific RNA-protein interactions via nanopore long-read sequencing

2026-01-22

Abstract excerpt

<h4>ABSTRACT</h4> RNA binding proteins (RBPs) control gene expression through their activities in essentially all processing steps of coding and noncoding RNAs and are dysregulated in disease. With >95% of human multi-exon genes undergoing alternative splicing, the inability to assign RBP sites to distinct RNA variants fundamentally limits our understanding of RNA regulation. We present dirCLIP, a method combinin...

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Literature Corpus work: fd338e98-0b3a-5b28-a8bc-abc8e38ce2f3
DOI: 10.64898/2026.01.22.701028

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