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Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1

25 Nov 2015

Abstract excerpt

Poly(ADP-ribose)polymerase 1 (PARP-1) is a key eukaryotic stress sensor that responds in seconds to DNA single-strand breaks (SSBs), the most frequent genomic damage. A burst of poly(ADP-ribose) synthesis initiates DNA damage response, whereas PARP-1 inhibition kills BRCA-deficient tumor cells selectively, providing the first anti-cancer therapy based on synthetic lethality. However, the mechanism underlying...

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PMID: 26626479
DOI: 10.1016/j.molcel.2015.10.032

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