Article

Processing of oxidatively damaged DNA dirty ends by APE1

2021-11-29

Abstract excerpt

<h4>ABSTRACT</h4> Reactive oxygen species attack the structure of DNA, thus altering its base-pairing properties. Consequently, oxidative stress-associated DNA lesions are a major source of the mutation load that gives rise to cancer and other diseases. Base excision repair (BER) is the pathway primarily tasked with repairing DNA base damage, with apurinic/apyrimidinic endonuclease (APE1) having both AP-endonucle...

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Literature Corpus work: d45a142b-fdae-55e3-b159-d72eb8c6bdef
DOI: 10.1101/2021.11.28.470279

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