Article

TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis

2021-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Methylation and demethylation of cytosines in DNA are believed to act as keystones of cell-specific gene expression through controlling chromatin structure and accessibility to transcription factors. Cancer cells have their own transcriptional programs and we sought to alter such a cancer-specific program by enforcing expression of the catalytic domain (CD) of the methylcytosine dioxygenase TET2...

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Literature Corpus work: d866e128-02f7-5f63-94cf-010f5a387625
DOI: 10.1101/2021.10.27.466063

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