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Article

TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis

29 Mar 2022

Abstract excerpt

Methylation and demethylation of cytosines in DNA are believed to act as keystones of cell-specific gene expression by controlling the chromatin structure and accessibility to transcription factors. Cancer cells have their own transcriptional programs, and we sought to alter such a cancer-specific program by enforcing expression of the catalytic domain (CD) of the methylcytosine dioxygenase TET2 in breast cancer...

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Identifiers

PMID: 35351824
DOI: 10.26508/lsa.202101283

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