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TET1 functions as a tumor suppressor in lung adenocarcinoma through epigenetic remodeling and immune modulation

11 Aug 2025

Abstract excerpt

BACKGROUND: Ten-Eleven Translocation (TET1-3) dioxygenases oxidize 5-methylcytosine (5mC) in DNA to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC), initiating DNA demethylation. Since their discovery in 2009, there have been contradictory reports regarding the roles of TET proteins in cancer. TET genes have been characterized as tumor suppressors because their...

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PMID: 40790761
DOI: 10.1186/s13072-025-00617-2

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