Article

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancers

2018-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Cancer cells frequently boost nucleotide metabolism (NM) to support their increased proliferation, but the consequences of elevated NM on tumor de-differentiation are mostly unexplored. Here, we identified a role for thymidylate synthase (TS), a NM enzyme and established drug target, in cancer cell de-differentiation and investigated its clinical significance in breast cancer (BC). In vitro , T...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 210b344b-ddc4-50b9-94e4-979c96760be5
DOI: 10.1101/321943

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thymidylate synthase maintains the de-differentiated state of aggressive breast cancersDOI 10.1101/321943Read

Thymidylate synthase is functionally associated with ZEB1 and contributes to the epithelial‐to‐mesenchymal transition of cancer cellsSemantic proximity Read

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read

Exposing the cellular situation: findings from single cell RNA sequencing in breast cancerSemantic proximity Read

Dihydropyrimidines sustain aggressive cancer states by stabilizing DPYSL2Semantic proximity Read

Targeting EMSY-mediated methionine metabolism is a potential therapeutic strategy for triple-negative breast cancerSemantic proximity Read

Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance roleSemantic proximity Read

TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesisSemantic proximity Read

Unveiling the oncogenic significance of thymidylate synthase in human cancersSemantic proximity Read

Invasive lobular carcinoma integrated multi-omics analysis reveals silencing of Arginosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistanceSemantic proximity Read

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer.Semantic proximity Read

Mitochondrial SHMT2 is a crucial therapeutic target in dedifferentiated thyroid cancerSemantic proximity Read

Contact-based transfer of thymidylate promotes collective tumor growthSemantic proximity Read