Article

<i>MATRIN3</i> deficiency triggers autoinflammation via cGAS-STING activation

2024-04-02

Abstract excerpt

Interferon-stimulated genes (ISGs) comprise a program of immune effectors important for host immune defense. When uncontrolled, ISGs play a central role in interferonopathies and other inflammatory diseases. The mechanisms responsible for turning on ISGs are not completely known. By investigating MATRIN3 (MATR3), a nuclear RNA-binding protein mutated in familial ALS, we found that perturbing MATR3 results in eleva...

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Literature Corpus work: 219c4d33-a1ce-5075-9073-56a99b88ba40
DOI: 10.1101/2024.04.01.587645

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