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Article

ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity

25 Jul 2019

Abstract excerpt

Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes-indicative of viral replication-are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1...

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PMID: 31404141
DOI: 10.3389/fimmu.2019.01763

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