Article

Suppression of MDA5-mediated antiviral immune responses by NSP8 of SARS-CoV-2

2020-08-12

Abstract excerpt

Melanoma differentiation-associated gene-5 (MDA5) acts as a cytoplasmic RNA sensor to detect viral dsRNA and mediates type I interferon (IFN) signaling and antiviral innate immune responses to infection by RNA viruses. Upon recognition of viral dsRNA, MDA5 is activated with K63-linked polyubiquitination and then triggers the recruitment of MAVS and activation of TBK1 and IKK, subsequently leading to IRF3 and NF-κB...

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Literature Corpus work: 61985545-abf6-512c-ad0c-fa5c0760cccc
DOI: 10.1101/2020.08.12.247767

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