Article

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

2022-07-13

Abstract excerpt

Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense. This requires discrimination between structurally highly similar self and nonself nucleic acids to avoid aberrant inflammatory responses as in the autoinflammatory disorder Aicardi-Goutières syndrome (AGS). How vast amounts of self RNA are shielded from immune recognition to prevent autoinflammation is not fully understood....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 578649b1-b421-5668-9437-f6d0d2503ddb
DOI: 10.1101/2022.07.12.499661

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNADOI 10.1101/2022.07.12.499661Read

Aicardi-Goutières Syndrome caused by SAMHD1 mutation: Pathogenesis and Beyond.Semantic proximity Read

Involvement of SAMHD1 in dNTP homeostasis and the maintenance of genomic integrity and oncotherapy (Review).Semantic proximity Read

The Role of Nucleases and Nucleic Acid Editing Enzymes in the Regulation of Self-Nucleic Acid SensingSemantic proximity Read

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral ResponseSemantic proximity Read

SAMHD1 Functions and Human Diseases.Semantic proximity Read

SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathwaysSemantic proximity Read

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseSemantic proximity Read

The Dynamic Interplay between HIV-1, SAMHD1, and the Innate Antiviral ResponseSemantic proximity Read

PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammationSemantic proximity Read

Interferons Induce Expression of SAMHD1 in Monocytes through Down-regulation of miR-181a and miR-30aSemantic proximity Read

Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent mannerSemantic proximity Read

Autoimmunity Risk Gene IRGM is a Master Negative Regulator of Interferon Response by Controlling the Activation of cGAS-STING and RIG-I-MAVS Signaling PathwaysSemantic proximity Read