Article

Endogenous retrovirus promotes the aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway

2024-02-13

Abstract excerpt

<title>Abstract</title> <p>The dysregulated differentiation of T lymphocyte play an important role in systemic lupus erythematosus (SLE). However, the underlying mechanism remains unclear. Here, we showed that many transcripts derived from human endogenous retroviruses (HERVs) were highly expressed in CD4<sup>+</sup> T cells from SLE patients due to DNA hypomethylation, some of which were characterized by double...

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Literature Corpus work: 665884db-077c-530e-bd1b-3d0ad1d64149
DOI: 10.21203/rs.3.rs-3939567/v1

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