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Article

The complex role of AIM2 in autoimmune diseases and cancers

20 May 2021

Abstract excerpt

Absent in melanoma 2 (AIM2) is a novel member of interferon (IFN)-inducible PYHIN proteins. In innate immune cells, AIM2 servers as a cytoplasmic double-stranded DNA sensor, playing a crucial role in the initiation of the innate immune response as a component of the inflammasome. AIM2 expression is increased in patients with systemic lupus erythematosus (SLE), psoriasis, and primary Sjogren's syndrome, indicating...

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PMID: 34014039
DOI: 10.1002/iid3.443

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