Article

Transcription factor co-occupancy shapes the somatic mutational landscapes across regulatory regions in liver cancer

2026-08-25

Abstract excerpt

Both global and local chromatin structure influence the heterogeneous distribution of somatic mutations across the cancer genome. For instance, at the local scale, DNA regions bound by transcription factors (TF) and other chromatin-associated proteins display elevated somatic mutation rates, due to variable DNA damage and repair at these protein-bound sites. However, the contribution of TF co-binding towards the v...

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Literature Corpus work: d82e628b-1765-5374-ba08-c8b4b78eb12a
DOI: 10.64898/2026.08.22.745658

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