Article

A Robust Framework for Predicting Mutation Effects on Transcription Factor Binding: Insights from Mutational Signatures in 560 Breast Cancer Genomes

2026-02-17

Abstract excerpt

<h4>Background</h4> A vast majority of somatic mutations in cancer reside in non-coding regions, yet systematically predicting their functional impact on gene regulation remains a significant challenge. These variants often enforce their effects by altering the binding affinity of transcription factors (TFs) to cis-regulatory elements. However, a critical gap exists in linking specific mutational processes to the...

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Literature Corpus work: 8516f23b-1538-5d0f-a592-4e47b0dd24bb
DOI: 10.64898/2026.02.14.705876

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