Article

Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancer

2020-01-15

Abstract excerpt

<title>Abstract</title> <p>Background: In recent years, it has been shown that many of the pervasive genetic defects in cancer occur in chromatin modifiers. In order to obtain insights in regards to their biology and clinical relevance in cancer, we analyzed the distribution and mutual relationships of genetic aberrations in relevant chromatin modifiers in tens of thousands of publicly available cancer datasets....

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Literature Corpus work: cb799da8-b58d-50ee-aba1-788e6ebc5438
DOI: 10.21203/rs.2.20947/v1

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