Article

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancers

2020-06-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Most cancer alterations occur in the noncoding portion of the human genome, which contains important regulatory regions acting as genetic switches to ensure gene expression occurs at correct times and intensities in correct tissues. However, large scale discovery of noncoding events altering the gene expression regulatory program has been limited to a few examples with high...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f8fb8816-3911-5053-af25-2643fb0bb458
DOI: 10.1101/2020.06.25.170738

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of the gene regulatory program in cancersDOI 10.1101/2020.06.25.170738Read

Cis-regulatory mutations associate with transcriptional and post-transcriptional deregulation of gene regulatory programs in cancers.Semantic proximity Read

A catalog of <i>cis</i> -regulatory mutations in 12 major cancer typesSemantic proximity Read

Transcription Factor-Centric Approach to Identify Non-Recurring Putative Regulatory Drivers in CancerSemantic proximity Read

Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas.Semantic proximity Read

Recurrent somatic mutations in regulatory regions of human cancer genomes.Semantic proximity Read

Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations.Semantic proximity Read

Motif Disruption Domains Lead To Cancer Gene Expression RewiringSemantic proximity Read

Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networksSemantic proximity Read

Systematic Pan-cancer Functional Inference and Validation of Hyper, Hypo and Neomorphic MutationsSemantic proximity Read

Regulatory variation: an emerging vantage point for cancer biology.Semantic proximity Read

Functional annotation of noncoding mutations in cancer.Semantic proximity Read

Dissecting the sources of gene expression variation in a pan-cancer analysis identifies novel regulatory mutations.Semantic proximity Read