Article

Hematopoietic-specific heterozygous loss of <i>Dnmt3a</i> exacerbates colitis-associated colon cancer

2022-12-31

Abstract excerpt

<h4>ABSTRACT</h4> Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy. Presence of CH in solid tumor patients, including colon cancer, correlates with shorter survival. We hypothesized that bone marrow-derived cells with heterozygous loss-of-function mutations of DNMT3A , the most common genetic alteration in CH, contribute to t...

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Literature Corpus work: d812177a-ea0e-510f-a3ea-581b5011af10
DOI: 10.1101/2022.12.30.522355

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