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Article

Clonal Hematopoiesis in Colorectal Cancer: Mechanisms and Implications.

Cancer medicine - 1 Aug 2026

Xia Chenyue, Lu Yi, Gu Jinhui

Abstract excerpt

Clonal hematopoiesis (CH) arises from the expansion of hematopoietic stem and progenitor cells bearing somatic mutations, often in genes linked to epigenetic regulation and inflammation. Once considered a benign age-related phenomenon, CH has gained increasing attention for its potential to influence cancer biology beyond hematologic malignancies. Recent studies have uncovered an unexpectedly high prevalence of...

Topics

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Clonal Hematopoiesis
Colorectal Neoplasms
Dioxygenases
DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Epigenesis, Genetic

Hematopoietic Stem Cells

Tumor Microenvironment

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Open in PubMed Open full text

Identifiers

PMID: 42576276
DOI: 10.1002/cam4.72151
PMCID: PMC13457665

Genes

DNMT3A
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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