Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.

doi:10.1084/jem.20230011

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Article

Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.

The Journal of experimental medicine - 6 Nov 2023

Feng Yang, Yuan Qingchen, Newsome Rachel C, Robinson Troy, Bowman Robert L, Zuniga Ashley N, Hall Kendra N, Bernsten Cassandra M, Shabashvili Daniil E, Krajcik Kathryn I, Gunaratne Chamara, Zaroogian Zachary J, Venugopal Kartika, Casellas Roman Heidi L, Levine Ross L, Chatila Walid K, Yaeger Rona, Riva Alberto, Jobin Christian, Kopinke Daniel, Avram Dorina, Guryanova Olga A

Abstract excerpt

Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy. Presence of CH in solid tumor patients, including colon cancer, correlates with shorter survival. We hypothesized that bone marrow-derived cells with heterozygous loss-of-function mutations of DNMT3A, the most common genetic alteration in CH, contribute to the pathogenesis of...

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PMID: 37615936
DOI: 10.1084/jem.20230011
PMCID: PMC10450614

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