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Article

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.

The Journal of clinical investigation - 1 May 2011

Steine Eveline J, Ehrich Mathias, Bell George W, Raj Arjun, Reddy Seshamma, van Oudenaarden Alexander, Jaenisch Rudolf, Linhart Heinz G

Abstract excerpt

Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated aberrant DNA methylation is targeted to specific genomic regions, whether this methylation also occurs in noncancerous cells, and whether these epigenetic events are maintained in the absence...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

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Source

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Identifiers

PMID: 21490393
DOI: 10.1172/JCI43169
PMCID: PMC3083798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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