Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Clonal evolution of colorectal cancer in IBD.

Nature reviews. Gastroenterology & hepatology - 1 Apr 2017

Choi Chang-Ho R, Bakir Ibrahim Al, Hart Ailsa L, Graham Trevor A

Abstract excerpt

Optimizing the management of colorectal cancer (CRC) risk in IBD requires a fundamental understanding of the evolutionary process underpinning tumorigenesis. In IBD, clonal evolution begins long before the development of overt neoplasia, and is probably accelerated by the repeated cycles of epithelial wounding and repair that are characteristic of the condition. Here, we review the biological drivers of mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomarkers, Tumor
Share to Cancer Genomics and Diagnostics
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Ferroptosis and cancer prognosis

Share to Genetic factors in colorectal cancer

Share to Genetic Predisposition to Disease

Share to Inflammatory Bowel Diseases

Source

Identifiers

PMID: 28174420
DOI: 10.1038/nrgastro.2017.1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clonal evolution of colorectal cancer in IBD.PMID 28174420Read ↗

From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and BiologySemantic proximity Read ↗

Molecular mechanisms in colitis-associated colorectal cancerSemantic proximity Read ↗

Somatic Evolution in Non-neoplastic IBD-Affected ColonSemantic proximity Read ↗

The landscape of somatic mutation in normal colorectal epithelial cellsSemantic proximity Read ↗

Evolutionary history of human colitis-associated colorectal cancer.Semantic proximity Read ↗

The Evolutionary Landscape of Colorectal Tumorigenesis: Recent Paradigms, Models, and Hypotheses.Semantic proximity Read ↗

Somatic evolution in non-neoplastic IBD-affected colonSemantic proximity Read ↗

New insights into the earliest stages of colorectal tumorigenesis.Semantic proximity Read ↗

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancersSemantic proximity Read ↗

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer.Semantic proximity Read ↗

Early mutational events and clonal dynamics in normal crypts: implications for colorectal tumorigenesis.Semantic proximity Read ↗

Unraveling the genomic landscape of colorectal cancer through mutational signatures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.