Article

Alcohol reverses the effects of <i>KCNJ6</i> (GIRK2) noncoding variants on excitability of human glutamatergic neurons

2022-05-24

Abstract excerpt

Synonymous and noncoding single nucleotide polymorphisms (SNPs) in the KCNJ6 gene, encoding G protein-gated inwardly rectifying potassium (GIRK2) channel subunit 2, have been linked with increased electroencephalographic frontal theta event-related oscillations (ERO) in subjects diagnosed with alcohol use disorder (AUD). To identify molecular and cellular mechanisms while retaining the appropriate genetic backgro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d7fb72b8-1608-5481-b07e-21f86ed07e83
DOI: 10.1101/2022.05.24.493086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alcohol reverses the effects of <i>KCNJ6</i> (GIRK2) noncoding variants on excitability of human glutamatergic neuronsDOI 10.1101/2022.05.24.493086Read

Upregulated GIRK2 counteracts ethanol-induced changes in excitability & respiration in human neuronsSemantic proximity Read

Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.Semantic proximity Read

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.Semantic proximity Read

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of ExcitabilitySemantic proximity Read

Molecular correlates of topiramate and <i>GRIK1</i> rs2832407 genotype in pluripotent stem cell-derived neural culturesSemantic proximity Read

Type I TARPs regulate Kv7.2 potassium channels and susceptibility to seizuresSemantic proximity Read

Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures.Semantic proximity Read

Molecular Deconstruction of the Medullary Raphe Magnus in the rat: Transcriptional Responses to Repeated SeizuresSemantic proximity Read

Molecular deconstruction of the pre-Bötzinger Complex/Nucleus Ambiguus (preBötC/NA) region: cellular constituencies and transcriptional responses to repeated seizures in the rat hindbrainSemantic proximity Read

Genome-wide association analysis links multiple psychiatric liability genes to oscillatory brain activity.Semantic proximity Read

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of <i>GRIN2A</i> haploinsufficiencySemantic proximity Read

GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.Semantic proximity Read