Article

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of <i>GRIN2A</i> haploinsufficiency

2025-06-09

Abstract excerpt

GluN2A-containing NMDA receptors, encoded by the GRIN2A gene, are critical components of excitatory synaptic transmission and are essential for proper brain development and function. Dysregulation of NMDA receptor activity is strongly implicated in the pathophysiology of epilepsy. While excessive GluN2A-mediated signalling can lead to hyperexcitability and seizure generation, loss-of-function mutations in GRIN2A...

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Literature Corpus work: 0732633b-114b-5b00-a70f-c94225c6ad9b
DOI: 10.1101/2025.06.09.658610

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