Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures.

doi:10.1111/acer.14399

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Molecular Correlates of Topiramate and GRIK1 rs2832407 Genotype in Pluripotent Stem Cell-Derived Neural Cultures.

Alcoholism, clinical and experimental research - 1 Aug 2020

Lieberman Richard, Jensen Kevin P, Clinton Kaitlin, Levine Eric S, Kranzler Henry R, Covault Jonathan

Abstract excerpt

BACKGROUND: There is growing evidence that the anticonvulsant topiramate is efficacious in reducing alcohol consumption. Further, an intronic single nucleotide polymorphism (rs2832407, C A) in the GRIK1 gene, which encodes the GluK1 subunit of the excitatory kainate receptor, predicted topiramate's effectiveness in reducing heavy drinking in a clinical trial. The molecular correlates of GRIK1 genotype that may...

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PMID: 32574382
DOI: 10.1111/acer.14399
PMCID: PMC7491603

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