Article

Upregulated GIRK2 counteracts ethanol-induced changes in excitability & respiration in human neurons

2023-03-23

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association analysis (GWAS) of electroencephalographic endophenotypes for alcohol use disorder (AUD) has identified non-coding polymorphisms within the KCNJ6 gene. KCNJ6 encodes GIRK2, a subunit of a G protein-coupled inwardly-rectifying potassium channel that regulates neuronal excitability. How changes in GIRK2 affect human neuronal excitability and the response to repeated ethan...

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Literature Corpus work: 63636a1a-827e-5c53-b6ef-b44463049f36
DOI: 10.1101/2023.03.22.533236

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