Article

Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability

2019-02-01

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in KCNQ2 , which encodes a pore-forming K + channel subunit responsible for neuronal M-current, cause neonatal epileptic encephalopathy, a complex disorder presenting with severe early-onset seizures and impaired neurodevelopment. The condition is exceptionally difficult to treat, partially because the effects of KCNQ2 mutations on the development and function of human neurons are u...

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Literature Corpus work: aabfda72-6615-51a9-83dc-93f9e711ac0c
DOI: 10.1101/538371

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