GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.

doi:10.1111/acer.12807

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GABRA2 Alcohol Dependence Risk Allele is Associated with Reduced Expression of Chromosome 4p12 GABAA Subunit Genes in Human Neural Cultures.

Alcoholism, clinical and experimental research - 1 Sept 2015

Lieberman Richard, Kranzler Henry R, Joshi Pujan, Shin Dong-Guk, Covault Jonathan

Abstract excerpt

BACKGROUND: Genetic variation in a region of chromosome 4p12 that includes the GABAA subunit gene GABRA2 has been reproducibly associated with alcohol dependence (AD). However, the molecular mechanisms underlying the association are unknown. This study examined correlates of in vitro gene expression of the AD-associated GABRA2 rs279858*C-allele in human neural cells using an induced pluripotent stem cell (iPSC)...

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Identifiers

PMID: 26250693
DOI: 10.1111/acer.12807
PMCID: PMC4558268

Genes

GABRA2
GABRA4
GABRB1
GABRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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