Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

doi:10.1002/ajmg.b.30818

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Article

Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Apr 2009

Chen Andrew C H, Tang Yongqiang, Rangaswamy Madhavi, Wang Jen C, Almasy Laura, Foroud Tatiana, Edenberg Howard J, Hesselbrock Victor, Nurnberger John, Kuperman Samuel, O'Connor Sean J, Schuckit Marc A, Bauer Lance O, Tischfield Jay, Rice John P, Bierut Laura, Goate Alison, Porjesz Bernice

Abstract excerpt

Evidence suggests the P3 amplitude of the event-related potential and its underlying superimposed event-related oscillations (EROs), primarily in the theta (4-5 Hz) and delta (1-3 Hz) frequencies, as endophenotypes for the risk of alcoholism and other disinhibitory disorders. Major neurochemical substrates contributing to theta and delta rhythms and P3 involve strong GABAergic, cholinergic and glutamatergic...

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Identifiers

PMID: 18618593
DOI: 10.1002/ajmg.b.30818
PMCID: PMC2660384

Genes

GRM8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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