Article

Molecular correlates of topiramate and <i>GRIK1</i> rs2832407 genotype in pluripotent stem cell-derived neural cultures

2019-07-22

Abstract excerpt

There is growing evidence that the anticonvulsant topiramate is efficacious in reducing alcohol consumption. Further, an intronic single nucleotide polymorphism (rs2832407, C ➔ A) in the GRIK1 gene, which encodes the GluK1 subunit of the excitatory kainate receptor, predicted topiramate’s effectiveness in reducing heavy drinking in a clinical trial. In the current study, we differentiated a total of 22 induced pl...

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Literature Corpus work: 83ef7a65-4966-576d-a3ed-c8343eecb517
DOI: 10.1101/710343

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