Article

PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains Treg homeostasis

2019-12-23

Abstract excerpt

Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme into the tricarboxylic acid (TCA) cycle. Here we show that PARK7/DJ-1, a key familial Parkinson’s disease (PD) gene, is a pacemaker controlling PDH activity in CD4 regulatory T cells (Tregs). DJ-1 bound to PDH-E1 beta (PDHB), inhibiting the phosphorylation of PDH-E1 alpha (PDHA), thus promoting PDH activity and oxidative phosphorylation (OXPHOS). Dj-1 depletio...

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Literature Corpus work: d7d12ce2-4bdf-5568-ad64-e0304bfc3b8b
DOI: 10.1101/2019.12.20.884809

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