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Article

DJ-1 Enhances Cell Survival through the Binding of Cezanne, a Negative Regulator of NF-κB

20 Nov 2010

Abstract excerpt

Heightened DJ-1 (Park7) expression is associated with a reduction in chemotherapeutic-induced cell death and poor prognosis in several cancers, whereas the loss of DJ-1 function is found in a subgroup of Parkinson disease associated with neuronal death. This study describes a novel pathway by which DJ-1 modulates cell survival. Mass spectrometry shows that DJ-1 interacts with BBS1, CLCF1, MTREF, and...

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PMID: 21097510
DOI: 10.1074/jbc.m110.147371

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