DJ-1 mediates regulation of metabolism and immune response in Parkinson’s disease astrocytes and Glioblastoma cells

Abstract excerpt

An inverse correlation for the expression of Parkinson’s disease (PD)- and cancer-associated genes has been previously reported. Genes that are upregulated in cancer are frequently downregulated in PD and vice versa . PARK7, encoding DJ-1, was initially identified as an oncogene, but loss of DJ-1 causes early-onset PD. However, it remains elusive how differential DJ-1 levels contribute to opposite cell fates in c...

Topics

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• Acetylcysteine
• Autophagy in Disease and Therapy
• Glioma Diagnosis and Treatment
• Histone Deacetylase Inhibitors Research
• Mitochondrial Function and Pathology
• Neuroinflammation and Neurodegeneration Mechanisms
• Nuclear Receptors and Signaling
• Parkinson's Disease Mechanisms and Treatments

Identifiers and source

Literature Corpus work

baa6b443-42a2-5deb-9135-ae28b42779c2

DOI

10.1101/2024.10.31.621212