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Article

PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic target

18 Apr 2023

Abstract excerpt

Microglia are the immune effector cells of the brain playing critical roles in immune surveillance and neuroprotection in healthy conditions, while they can sustain neuroinflammatory and neurotoxic processes in neurodegenerative diseases, including Parkinson's disease (PD). Although the precise triggers of PD remain obscure, causative genetic mutations, which aid in the identification of molecular pathways...

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PMID: 37072827
DOI: 10.1186/s12974-023-02776-z

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