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Article

The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

Nature cell biology - 1 May 2015

Etchegaray Jean-Pierre, Chavez Lukas, Huang Yun, Ross Kenneth N, Choi Jiho, Martinez-Pastor Barbara, Walsh Ryan M, Sommer Cesar A, Lienhard Matthias, Gladden Adrianne, Kugel Sita, Silberman Dafne M, Ramaswamy Sridhar, Mostoslavsky Gustavo, Hochedlinger Konrad, Goren Alon, Rao Anjana, Mostoslavsky Raul

Abstract excerpt

How embryonic stem cells (ESCs) commit to specific cell lineages and yield all cell types of a fully formed organism remains a major question. ESC differentiation is accompanied by large-scale histone and DNA modifications, but the relations between these epigenetic categories are not understood....

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Identifiers

PMID: 25915124
DOI: 10.1038/ncb3147
PMCID: PMC4593707

Genes

SIRT6
NANOG
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25915124-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.PMID 25915124Read ↗

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