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Article

Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors.

Acta neuropathologica communications - 6 May 2024

Perycz Malgorzata, Dabrowski Michal J, Jardanowska-Kotuniak Marta, Roura Adria-Jaume, Gielniewski Bartlomiej, Stepniak Karolina, Dramiński Michał, Ciechomska Iwona A, Kaminska Bozena, Wojtas Bartosz

Abstract excerpt

The RE1-silencing transcription factor (REST) acts either as a repressor or activator of transcription depending on the genomic and cellular context. REST is a key player in brain cell differentiation by inducing chromatin modifications, including DNA methylation, in a proximity of its binding sites. Its dysfunction may contribute to oncogenesis. Mutations in IDH1/2 significantly change the epigenome contributing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38711090
DOI: 10.1186/s40478-024-01779-y
PMCID: PMC11071216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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Comprehensive analysis of the REST transcription factor regulatory networks in IDH mutant and IDH wild-type glioma cell lines and tumors.PMID 38711090Read ↗

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