Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant glioma

Abstract excerpt

<h4>ABSTRACT</h4> Inactivating mutations in ATRX characterize large subgroups of malignant gliomas in adults and children. ATRX deficiency in glioma induces widespread chromatin remodeling, driving transcriptional shifts and oncogenic phenotypes. Effective strategies to therapeutically target these broad epigenomic sequelae remain undeveloped. We utilized integrated mulit-omics and the Broad Institute Connectivi...

Topics

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• Chromatin Assembly and Disassembly
• Gene Silencing
• Genes, p53
• Glioma
• GTP-Binding Protein alpha Subunits, G12-G13
• Neural Stem Cells
• rhoA GTP-Binding Protein
• X-linked Nuclear Protein

Identifiers and source

Literature Corpus work

4c3736a9-40a2-5811-a8bd-8b701ff8ae73

DOI

10.1101/2023.01.09.523324