Article

Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging

2023-09-21

Abstract excerpt

Demyelination occurs in aging and associated diseases, including Alzheimer’s disease. Several of these diseases exhibit sex differences in prevalence and severity. Biological sex primarily stems from sex chromosomes and gonads releasing sex hormones. To dissect mechanisms underlying sex differences in demyelination of aging brains, we constructed a transcriptomic atlas of cell type-specific responses to illustrate...

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Literature Corpus work: d77a2399-b3ac-5d27-8337-1480017aab3d
DOI: 10.1101/2023.09.19.558439

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Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During AgingDOI 10.1101/2023.09.19.558439Read

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