Sex differences in progressive multiple sclerosis brain gene expression in oligodendrocytes and OPCs

Abstract excerpt

Multiple sclerosis is a neurological autoimmune disease with sex-imbalanced incidence; in the USA, the disease is more likely to effect females at a ratio of 3:1. In addition, males are more likely to have a more severe disease course at time of diagnosis. Questions about both causes and downstream effects of this disparity remain. We aim to investigate gene expression differences at a cellular level while conside...

Topics

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• Antigen Presentation
• Bioinformatics and Genomic Networks
• CD40 Antigens
• Chromosomes, Human, Pair 12
• Cytokine Signaling Pathways and Interactions
• Gene Expression Profiling
• Linkage Disequilibrium
• Multiple Sclerosis Research Studies

Identifiers and source

Literature Corpus work

4703f707-55e7-5bc3-8245-2b69c8471791

DOI

10.1101/2025.02.05.636293