Article

Understanding Sex Differences in Autoimmune Diseases: Immunologic Mechanisms

2025-06-11

Abstract excerpt

Autoimmune diseases such as systemic lupus erythematosus and Sjögren’s syndrome show pronounced sex disparities in prevalence, severity, and clinical outcomes, with females disproportionately affected. Emerging evidence highlights sex-based differences in immune and inflammatory responses as key contributors to this bias. Genetic factors—including sex chromosomes, skewed X chromosome inactivation, and sex-biased m...

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Literature Corpus work: 2e05f6bc-b1cc-5506-8f94-de91be596d07
DOI: 10.20944/preprints202506.0943.v1

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