Article

Aging Differentially Alters the Transcriptome and Landscape of Chromatin Accessibility in the Male and Female Mouse Hippocampus

2023-10-17

Abstract excerpt

Aging-related memory impairment and pathological memory disorders such as Alzheimer’s disease differ between males and females, and yet little is known about how aging-related changes in the transcriptome and chromatin environment differ between sexes in the hippocampus. To investigate this question, we compared the chromatin accessibility landscape and gene expression/alternative splicing pattern of young adult a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ef04713-ec61-568c-b930-e19dd0374264
DOI: 10.1101/2023.10.17.562606

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Aging Differentially Alters the Transcriptome and Landscape of Chromatin Accessibility in the Male and Female Mouse HippocampusDOI 10.1101/2023.10.17.562606Read

Age-associated transcriptomic and epigenetic alterations in mouse hippocampusSemantic proximity Read

Changes in microglia chromatin accessibility in aged female miceSemantic proximity Read

Sexually divergent DNA methylation programs with hippocampal agingSemantic proximity Read

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and genderSemantic proximity Read

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlasSemantic proximity Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

A spatiotemporal map of the aging mouse brain reveals white matter tracts as vulnerable fociSemantic proximity Read

Targeting the hypothalamus for modeling age-related DNA methylation and developing OXT-GnRH combinational therapy against Alzheimer’s disease-like pathologies in male mouse modelSemantic proximity Read

Differential regulation of mouse hippocampal gene expression sex differences by chromosomal content and gonadal sexSemantic proximity Read

Early life DNA methylation profiles are indicative of age-related transcriptome changesSemantic proximity Read

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read

Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responsesSemantic proximity Read